Gongsun Zan participates as one of the commanders on the Allied Forces allied against Dong Zhuo. He serves at the Battle of Hu Lao Gate. In Dynasty Warriors 5, the Battle of Chang Shan was added, where Gongsun Zan fights against Yuan Shao. This is his last appearance in the game, as he dies in the battle, afterwhich Zhao Yun, one of his officers, leaves to fight with Liu Bei.

If the player chooses to defend him, he becomes an officer of He Jin's Shu division.